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Risk of Heart Attack Doubles Following Mini Strokes

Patients who have suffered a "mini stroke" are at twice the risk of heart attack than the general population, according to research reported in Stroke: Journal of the American Heart Association.

These mini-strokes, called transient-ischemic attacks, or TIAs, occur when a blood clot temporarily blocks a blood vessel to the brain. Although the symptoms are similar to a stroke, a TIA is shorter - usually lasting only minutes or a few hours - and does not cause long-term disability. A TIA, also called a "warning stroke," signals a high risk of a subsequent, larger stroke.

In this study, the risk of heart attack among TIA patients was about 1 percent per year, double that of people who had never had a TIA. This increased risk persisted for years and was highest among patients under age 60, who were 15 times more likely than non-TIA patients to have a heart attack.

Factors that independently increased the risk of heart attack after TIA included:
  • male gender;
  • older age; and
  • use of cholesterol-lowering medications (although patients using these drugs may have had more severe heart disease initially).
The study included 456 patients (average age 72, 43 percent men) diagnosed with a TIA between 1985 and 1994. Nearly two-thirds had high blood pressure, more than half smoked, and three-fourths were being treated with medication, such as aspirin, to prevent blood clots. Average follow-up was 10 years.

Co-authors are Joseph D. Burns, M.D.; Alejandro A. Rabinstein, M.D.; Veronique L. Roger, M.D., M.P.H.; Latha G. Stead, M.D.; Teresa J. H. Christianson, B.S.; and Jill M. Killian, B.S. Author disclosures are on the manuscript.

The Mayo Clinic funded the study. TIA and stroke warning signs are sudden:
  • Numbness or weakness of the face, arm or leg, often on only one side of the body
  • Confusion and trouble speaking or understanding others
  • Difficulty seeing
  • Trouble walking, feelings of dizziness and loss of balance or coordination
  • Severe headache of unknown cause
If you have any of these signs, call 9-1-1 for immediate medical attention.

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